PKIN Reference > Compartment Models for Cardiac PET

Model Name	Description
Card. NH3 (de Grado)	1-Tissue compartment model with two spillover terms. Has been developed for cardiac NH3-PET studies with bolus administration. The left ventricle input curve is linearly corrected for metabolites.
Card. NH3 (UCLA, 2 Parameters)	2-Tissue compartment model with only 2 fitted parameters. Has been developed for cardiac NH3-PET studies with bolus administration. It only uses the first 2 minutes of the data as there is not metabolite correction included.
Card. NH3 (2 Compartments)	2-Tissue compartment model with metabolic trapping. Has been developed for cardiac NH3-PET studies with bolus administration. Also implements metabolite correction.
Card. Rb-82 (1 Compartment)	1-compartment model for the quantification of myocardial perfusion with Rubidium-82 PET data.
Card. Rb-82 (2 Compartment)	Two-compartment model for the quantification of myocardial perfusion with Rubidium-82 PET data.
Card. H2O (Tissue fraction)	1-Tissue compartment model with two spillover terms. Has been developed for cardiac H215O- PET studies with bolus administration.
Card. H2O (Geometrical corr.)	As above, but with geometrical spillover correction.
Card. Acetate (1 Compartment)	1-compartment model for the quantification of myocardial perfusion with 11C Acetate PET data.

Assumptions of the Cardiac Models

▪The cardiac models usually apply a geometrical spillover with two correction terms: correction for signal from the left and right ventricular cavity.

▪For calculating the myocardial perfusion per g tissue a density of 1.04 g/ml for myocardial tissue is applied.

▪Usually the PET signal from the left ventricle or the atrium is used as a measure of the tracer activity in blood. Depending on the tracer, corrections are applied to this blood curve for calculation the concentration of parent tracer with is required as the input curve of the models.

Exceptions to these rules are specified in the description of the individual models.