The 1-Tissue Compartment Model only separates tissue uptake and washout. All tracer in tissue is included in a single compartment C1.
Differential Equation of the Mass Balance
with input curve Cp(t), tissue concentration C1(t), uptake rate constant K1 [ml/ccm/min] and clearance rate constant k2 [1/min].
Operational Model Curve
with the concentration CB(t) of tracer in whole blood, and the blood volume fraction vB.
Parameter Fitting
The model includes the three fitable parameters vB, K1, k2. Often, vB is fixed at a physiologic value of 3-5%.