<< Click to Display Table of Contents >> Navigation:  PKIN Data Processing > Configuration and Fitting of Kinetic Tissue Models > Kinetic Model Fitting > Iterative Fitting Principle

For most models, minimization of the Chi square expression requires an iterative approach. The procedure starts with a set of initial parameter values, generates the corresponding model curve, calculates the Chi square criterion, and adjusts the model parameters such that Chi square is expected to be reduced. The cycle

▪chi square calculation

▪parameter adjustment

is then repeated until a further reduction of Chi square is not any more possible. The final set of parameters upon termination is regarded as the best-fit result. It is not analytically exact and may depend on the initial parameters, on the optimization procedure, and on the termination criterion of the iterations.